Lipid nanodomains change ion channel function
نویسندگان
چکیده
منابع مشابه
Lipid nanodomains change ion channel function.
Signaling proteins and neurotransmitter receptors often associate with saturated chain and cholesterol-rich domains of cell membranes, also known as lipid rafts. The saturated chains and high cholesterol environment in lipid rafts can modulate protein function, but evidence for such modulation of ion channel function in lipid rafts is lacking. Here, using raft-forming model membrane systems con...
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Lipid rafts, defined as domains rich in cholesterol and sphingolipids, are involved in many important plasma membrane functions. Recent studies suggest that the way cells handle membrane cholesterol is fundamental in the formation of such lateral heterogeneities. We propose to model the plasma membrane as a nonequilibrium phase-separating system where cholesterol is dynamically incorporated and...
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ژورنال
عنوان ژورنال: Nanoscale
سال: 2017
ISSN: 2040-3364,2040-3372
DOI: 10.1039/c7nr03926c